منابع مشابه
Aptamers as Both Drugs and Drug-Carriers
Aptamers are short nucleic acid oligos. They may serve as both drugs and drug-carriers. Their use as diagnostic tools is also evident. They can be generated using various experimental, theoretical, and computational techniques. The systematic evolution of ligands by exponential enrichment which uses iterative screening of nucleic acid libraries is a popular experimental technique. Theory inspir...
متن کاملPerspective: Aptamers as Drugs
Aptamers are nucleic acid molecules, either single-stranded RNA or DNA, that form secondary structures capable of eliciting affinities to a variety of targets ranging from small organics to whole proteins. They can be quickly developed and are relatively inexpensive to manufacture. Aptamers have the potential to be used as novel drug products, but lacks general acceptance within the pharmaceuti...
متن کاملTherapeutic aptamers: developmental potential as anticancer drugs
Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are selected from pools of combinatorial oligonucleotide libraries. With their high specificity and affinity for target proteins, ease of synthesis and modification, and low immunogenicity and toxicity, aptamers are considered to be attractive mol...
متن کاملNanoparticles as Drug Carriers DRUG TARGETING OF DRUGS AND NUCLEIC ACIDS
One of the primary objectives in the development of drug delivery systems is the controlled delivery of a drug to its site of action at an optimal rate and in the most efficient way possible [1]. Targeting a drug to its site of action not only improves the therapeutic efficacy but also enables a reduction in total dose of the drug, thus minimizing unwanted toxic effects. This goal may be achiev...
متن کاملLiposomes as drug carriers.
Liposomes are artificially prepared vesicles made of lipid bilayer. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Amongst the various carrier, few drug carrier reached the stages of clinical trails where phospholipid vesicles (liposome) show strong potential for effective drug delivery to the site of action. Liposomes can be composed of naturally-d...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2014
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2014/697923